Therefore, factors other than B2M accumulation seem to play a role in deposition of B2M in osteoarticular tissues. 9 Systemic B2M amyloidosis was systemically observed in patients on long-term dialysis these patients had chronic kidney failure and high serum B2M concentrations.
8 Although acidic conditions favorable to formation of B2M in vivo are not always physiological, B2M fibrils are deposited primally in osteoarticular tissues around the joints of DRA patients undergoing dialysis. High local concentrations of B2M at an optimal pH of 2–3, or stabilization of B2M molecules, favor nucleation. All rights reserved.All subjects Allied Health Cardiology & Cardiovascular Medicine Dentistry Emergency Medicine & Critical Care Endocrinology & Metabolism Environmental Science General Medicine Geriatrics Infectious Diseases Medico-legal Neurology Nursing Nutrition Obstetrics & Gynecology Oncology Orthopaedics & Sports Medicine Otolaryngology Palliative Medicine & Chronic Care Pediatrics Pharmacology & Toxicology Psychiatry & Psychology Public Health Pulmonary & Respiratory Medicine Radiology Research Methods & Evaluation Rheumatology Surgery Tropical Medicine Veterinary Medicine Cell Biology Clinical Biochemistry Environmental Science Life Sciences Neuroscience Pharmacology & Toxicology Biomedical Engineering Engineering & Computing Environmental Engineering Materials Science Anthropology & Archaeology Communication & Media Studies Criminology & Criminal Justice Cultural Studies Economics & Development Education Environmental Studies Ethnic Studies Family Studies Gender Studies Geography Gerontology & Aging Group Studies History Information Science Interpersonal Violence Language & Linguistics Law Management & Organization Studies Marketing & Hospitality Music Peace Studies & Conflict Resolution Philosophy Politics & International Relations Psychoanalysis Psychology & Counseling Public Administration Regional Studies Religion Research Methods & Evaluation Science & Society Studies Social Work & Social Policy Sociology Special Education Urban Studies & Planning BROWSE JOURNALS Moreover, the pooled adjusted RRs were 2.51 (1.94-3.26 I 2 = 83.7%) for all-cause mortality and 2.64 (1.34-5.23 I 2 = 83.1%) for infectious mortality.Īvailable observational data show that there are moderate positive associations between B2M levels and CVD events and mortality, although few studies have been conducted in general populations.īeta-2-microglobulin Cardiovascular diseases Meta-analysis Mortality.Ĭopyright © 2021 The Authors. The positive associations between B2M and risks of CVD outcomes remained broadly significant across subgroup analyses. Based on random-effects meta-analysis, the pooled adjusted RRs comparing the highest versus lowest third of the distribution of B2M were 1.71 (95%CI: 1.37-2.13) for CVD, 2.29 (1.51-3.49) for CVD mortality, 1.64 (1.14-2.34) for CHD, and 1.51 (1.28-1.78) for stroke, with little to high heterogeneity between studies (0.0% ≤ I 2 ≤ 80.0%). Sixteen studies (5 in general populations, and 11 in renal disease populations) were included, involving 30,988 participants and 5391 CVD events. Relative risks (RR) were extracted and harmonized to a comparison of the highest versus lowest third of the distribution of B2M, and the results were aggregated. We identified studies that reported associations of baseline serum or plasma B2M and CVD incidence, CVD mortality, or CHD and stroke separately, in either general populations or patients with renal disease. Three databases were searched from inception to January 2, 2020, supplemented by scanning reference lists of identified studies. Beta-2-microglobulin (B2M) has been suggested as an emerging biomarker for cardiovascular diseases (CVD), including coronary heart disease (CHD) and stroke, and mortality.
0 kommentar(er)
